Infertility has a profound social, emotional and psychological impact on individuals. The couples are often desperate for quick results and are willing to follow any treatment advised for quick results. This desperation invariably catches up with the medical professionals treating them. As a result, various Add-ons have been included in the prescription. This is the genesis of Add-ons in the practice of reproductive medicine. Of these, antioxidants have emerged as the most commonly used medications as a panacea for severe male infertility and for enhancing female fertility. In this paper, we try to dispel this claim with scientific rationale and bring in evidence for its potential adverse effects.