The Journal of the Association of Physicians of Tamil Nadu Issue 3

A Case of Inherited Channelopathy-Liddle’s Syndrome

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Unlock Image Volume 4, Issue 3 ,  September 2025 ,  Pages 63-64
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AUTHORS

S. Aravind1,  Gunasekaran Mahalingam2, ✲

1 –  Consultant Physician, Green Health Hospital, Pattukkottai, Thanjavur, Tamil Nadu, India.
2 –  Senior Consultant Physician, Dravidian Speciality Hospital, Pattukkottai, Thanjavur, Tamil Nadu, India.
✲ –  drgunamd1999@yahoo.com

CORRESPONDING AUTHOR

Gunasekaran Mahalingam

HISTORY

Available Online: September 2025

ABSTRACT

Liddle’s syndrome is a rare inherited cause of secondary hypertension, occurring due to epithelial sodium channel (ENaC) mutations. It presents either in childhood or early adulthood, as hypertension with hypokalemia, similar to mineralocorticoid excess or primary hyperaldosteronism. It can be differentiated by suppressed levels of renin and aldosterone. Treatment consists of salt restriction and ENaC blockers. Here is discussed an interesting case of Liddle’s syndrome.

KEYWORDS

Hypertension, Hypokalemia, Liddle’s Syndrome

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This is an open access article distributed under the CC BY 4.0 license

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COPYRIGHT

© 2026 Association of Physicians of India-Tamilnadu State Chapter. Published by Dr. Vijay Viswanathan

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