With a year almost complete following the arrival of the global threat, the world has adapted to the General measures of prevention with the use of masks, social distancing, and practicing self-hygiene. Another widely discussed topic right from the surfacing of the pandemic is that on the vaccines. On a large scale, the use of vaccines itself has been a matter of debate, but the identification of COVID vaccines, the type of the vaccine, its efficacy, the dosage schedule, the eligible candidates, its safety profile, its impact on the economy and the plausibility of the effective cold chain have been in the limelight among both the general public and the health professionals. This article aims to provide insight into the above addressed topics and shower some light on the possible efficacy of other vaccines for protection against SARSCoV, which were originally designed to combat other disease conditions.